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Fig. 5 | Biological Research

Fig. 5

From: Allergens of the urushiol family promote mitochondrial dysfunction by inhibiting the electron transport at the level of cytochromes b and chemically modify cytochrome c1

Fig. 5

Both catecholic and aliphatic moieties are required for the inhibition of coupled respiration. The effects of litreol, poison oak, and compounds structurally related to urushiols on mitochondrial respiration were compared using 2.8 mM glutamate-malate as a substrate for respiration and 0.28 ADP as the initiator of the reaction. The control rate for ADP-stimulated glutamate + malate oxidation was 66.0 nmol O/min/mg protein in the presence of 0.28 mM ADP. Poison ivy/oak (black square), 3-pentadecyl catechol (black up-pointing triangle), 3-methyl catechol (black circle), 3-pentadecyl phenol (black down-pointing triangle), and litreol (black diamond suit). Poison ivy/oak vs pentadecyl catechol or litreol: p < 0.05; litreol vs pentadecyl catechol: not significant

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Biological Research

ISSN: 0717-6287

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