Fig. 5
From: Study on the therapeutic potential of induced neural stem cells for Alzheimer's disease in mice
A Electron microscopy images showing the ultrastructure of neurons in the transplanted hippocampal region. In both the WT group and AD + iNSCs group, a greater number of synapses (bold arrows) were observed compared to the AD + PBS group. In the AD + PBS group, notable mitochondrial swelling and disrupted cristae structure (thin arrow) were observed within nerve cells. B Quantification of the number of synapses in the hippocampal region by EM analysis. AD + iNSCs mice showed a higher number of synapses compared with AD + PBS mice. One-way ANOVA. C Typical Western blot of different proteins(Map2, olig2, GFAP and Nestin) in the hippocampal region. D Quantification of total protein levels was significantly higher in AD + iNSCs and in WT compared with AD mice and AD + PBS mice. One-way ANOVA, *P < 0.05, ***P < 0.01