Fig. 8

The role of COX signaling in endothelium-dependent vasorelaxation (a, b) and adrenergic contraction (c, d) of isolated thoracic aorta in female Wistar and HTG rats. W Wistar female rats, HTG hereditary hypertriglyceridemic female rats, A– perivascular adipose tissue denuded rings, A+ perivascular adipose tissue preserved rings, INDO– rings without incubation with COX inhibitor (indomethacin), INDO+ rings incubated with COX inhibitor (indomethacin). The results are presented as the mean ± S.E.M., and differences between groups were analyzed by three-way ANOVA. c: ***p < 0.001 vs W A– INDO–, ⁺⁺⁺p < 0.001 vs HTG A– INDO–, b, d: ***p < 0.001 vs W A+ INDO–, ⁺p < 0.05 vs HTG A+ INDO–