Fig. 1
From: NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion
Structural components of active NOX and DUOX enzymes. Key elements that form the active NOX and DUOX enzymes, which are crucial for the generation of reactive oxygen species (ROS). NOX1, NOX2, and NOX3 are shown to share common structural features and rely on cytosolic subunits for their activation. In contrast, NOX4 is depicted as being constitutively active, although it has been described as further modulated by interaction with POLIDIP2. The figure also highlights that NOX5 and the DUOX isoforms respond to changes in intracellular calcium concentrations