Fig. 3
From: Ptprd deficiency promotes tau hyperphosphorylation and impairs cognitive function in aged mice
Ptprd KO mice show impairments in learning and memory. 18-month-old Ptprd WT and Ptprd KO mice were tested in the MWM test, and the latency time to find the platform during the 4 days of training was assessed (A). On day 5, memory was evaluated by analyzing the trajectory of mice in the platform zone. A representative heat map of Ptprd WT and Ptprd KO mice trajectory is shown in (B, platform represented in the right bottom), which was analyzed to quantify the time in the platform zone (C), the distance traveled inside the platform zone (D), and the mean swimming speed (E). *p < 0.05, **p < 0.01; n = 7