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  1. Resveratrol was reported to trigger the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats but the subcellular mechanism remains unclear. Since ER stress, mitochondrial dysfunction and oxidat...

    Authors: Jinsen Lu, Jiazhao Yang, Yongshun Zheng, Shiyuan Fang and Xiaoyu Chen
    Citation: Biological Research 2019 52:45
    Content type: Research article Published on:

  2. Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-sti...

    Authors: Sulaiman K. Marafie, Eman M. Al-Shawaf, Jehad Abubaker and Hossein Arefanian
    Citation: Biological Research 2019 52:44
    Content type: Research article Published on:

  3. Drought is one of the main serious problems for agriculture production which its intensity is increasing in many parts of the world, hence, improving water use efficiency is a main goal for sustainable agricul...

    Authors: Somayeh Faghih, Zabihollah Zamani, Reza Fatahi and Abdolmajid Liaghat
    Citation: Biological Research 2019 52:43
    Content type: Research article Published on:

  4. Prognosis remains one of most crucial determinants of gastric cancer (GC) treatment, but current methods do not predict prognosis accurately. Identification of additional biomarkers is urgently required to ide...

    Authors: Wei Li, Yan Chen, Xuan Sun, Jupeng Yang, David Y. Zhang, Daguang Wang and Jian Suo
    Citation: Biological Research 2019 52:42
    Content type: Research article Published on:

  5. Di-N-butyl-phthalate (DBP) is an endocrine disrupting substance. We investigated the adverse effect of DBP on testis of male rat and reveal its potential mechanism of MAPK signaling pathway involved this effect i...

    Authors: Hongyan Wang, Weipeng Zhou, Jing Zhang and Huan Li
    Citation: Biological Research 2019 52:41
    Content type: Research article Published on:

  6. There are currently a number of barriers hindering the successful treatment of breast cancer, including the metastatic spread of cancer cells. In looking for new anticancer agents, we reported two novel hydraz...

    Authors: Soudeh Dehghani, Zahra Kooshafar, Ali Almasirad, Raheleh Tahmasvand, Fariborz Moayer, Ahad Muhammadnejad, Samira Shafiee and Mona Salimi
    Citation: Biological Research 2019 52:40
    Content type: Research article Published on:

  8. Breast cancer is the second common malignant cancer among females worldwide. Accumulating studies have indicated that deregulation of miRNA expression in breast cancer will contribute to tumorigenesis and form...

    Authors: Bao Zhang, Dattatrya Shetti, Conghui Fan and Kun Wei
    Citation: Biological Research 2019 52:38
    Content type: Research article Published on:

  9. Berberine (BBR), a compound extracted from a variety of medicinal herbs, has been shown multiple pharmacological effects against cancer cells of different origins. Cisplatin (DDP) is known as an effective chem...

    Authors: Li Liu, Jingyan Fan, Guihai Ai, Jie Liu, Ning Luo, Caixia Li and Zhongping Cheng
    Citation: Biological Research 2019 52:37
    Content type: Research article Published on:

  10. Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) c...

    Authors: Wenting Wang, Mingyue Zhu, Zhixin Xu, Wei Li, Xu Dong, Yi Chen, Bo Lin and Mengsen Li
    Citation: Biological Research 2019 52:36
    Content type: Research article Published on:

  11. Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it diffi...

    Authors: Hyunhee Do, Dain Kim, JiHoon Kang, Beomseok Son, Danbi Seo, HyeSook Youn, BuHyun Youn and Wanyeon Kim
    Citation: Biological Research 2019 52:35
    Content type: Research article Published on:

  12. Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been ...

    Authors: Xiaomin Wang, Peike Peng, Zhiqiang Pan, Zhaoqin Fang, Wenli Lu and Xiaomei Liu
    Citation: Biological Research 2019 52:34
    Content type: Research article Published on:

  13. Studies have shown that cancer susceptibility candidate 11 (CASC11), a newly discovered long non-coding RNA (lncRNA), was aberrantly overexpressed in hepatic carcinoma, gastric cancer and colorectal cancer. Howev...

    Authors: Wenchan Hsu, Lifen Liu, Xin Chen, Ying Zhang and Weipei Zhu
    Citation: Biological Research 2019 52:33
    Content type: Research article Published on:

  16. Chronic prostatitis has been supposed to be associated with preneoplastic lesions and cancer development. The objective of this study was to examine how chronic inflammation results in a prostatic microenviron...

    Authors: Yong Gao, Lijuan Wei, Chenbang Wang, Yuanjie Huang, Weidong Li, Tianyu Li, Chaohua Mo, Huali Qin, Xiaoge Zhong, Yun Wang, Aihua Tan, Zengnan Mo, Yonghua Jiang and Yanling Hu
    Citation: Biological Research 2019 52:30
    Content type: Research article Published on:

  17. Acute kidney injury (AKI), which is mainly caused by sepsis, has high morbidity and mortality rates. CXCL8(3–72) K11R/G31P (G31P) can exert therapeutic effect on inflammatory diseases and malignancies. We aimed t...

    Authors: Yunfeng Zhou, Wenda Xu and Hong Zhu
    Citation: Biological Research 2019 52:29
    Content type: Research article Published on:

  18. Hypoxic-ischemic encephalopathy (HIE) is a common disease that occurs during the perinatal period. The primary cause of neonatal HIE is related to fetal intrauterine anoxia. Carbamylated erythropoietin (CEPO),...

    Authors: Min Diao, Yi Qu, Hui Liu, Yushan Ma and Xuemei Lin
    Citation: Biological Research 2019 52:28
    Content type: Research article Published on:

  19. To assess the expression of T-box transcription factor 4 (TBX4) during the anorectal development in normal and ethylenethiourea (ETU)-induced anorectal malformations (ARM) rat embryos.

    Authors: Meng Li, Hailan Zhang, Huiying Liu, Hongzhong Tian, Xiaobing Tang, Yuzuo Bai and Weilin Wang
    Citation: Biological Research 2019 52:27
    Content type: Research article Published on:

  20. Acute myeloid leukemia (AML) is an aggressive and mostly incurable hematological malignancy with frequent relapses after an initial response to standard chemotherapy. Therefore, novel therapies are urgently re...

    Authors: Yubin Feng, Xiaoxiao Hua, Ruowen Niu, Yan Du, Congjian Shi, Renpeng Zhou and Fei-Hu Chen
    Citation: Biological Research 2019 52:26
    Content type: Research article Published on:

  21. The morphological diversity of flower organs is closely related to functional divergence within the MADS-box gene family. Bryophytes and seedless vascular plants have MADS-box genes but do not have ABCDE or AGAMO...

    Authors: Gangxu Shen, Chih-Hui Yang, Chi-Yen Shen and Keng-Shiang Huang
    Citation: Biological Research 2019 52:25
    Content type: Research article Published on:

  23. Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodel...

    Authors: Haiying Wei, Lili Lin, Xiaomei Zhang, Zhuolei Feng, Yeqing Wang, Yan You, Xiaodan Wang and Yongsheng Hou
    Citation: Biological Research 2019 52:23
    Content type: Research article Published on:

  24. Tumor microenvironment (TME) plays a vital role in determining the outcomes of radiotherapy. As an important component of TME, vascular endothelial cells are involved in the perivascular resistance niche (PVRN...

    Authors: Qianwen Li, Yan Zong, Ke Li, Xiaohua Jie, Jiaxin Hong, Xiaoshu Zhou, Bian Wu, Zhenyu Li, Sheng Zhang, Gang Wu and Rui Meng
    Citation: Biological Research 2019 52:22
    Content type: Research article Published on:

  25. Defects in DNA methylation have been shown to be associated with metabolic diseases such as obesity, dyslipidemia, and hypercholesterolemia. To analyze the methylation profile of the ADRB3 gene and correlate it w...

    Authors: Raquel Patrícia Ataíde Lima, Marina Ramalho Ribeiro, Keylha Querino de Farias Lima, Elisama Araújo de Sena, Diego de Oliveira Costa, Rafaella Cristhine Pordeus Luna, Rayner Anderson Ferreira do Nascimento, Maria da Conceição Rodrigues Gonçalves, Rodrigo Pinheiro de Toledo Vianna, Ronei Marcos de Moraes, Naila Francis Paulo de Oliveira, Aléssio Tony Cavalcanti de Almeida and Maria José de Carvalho Costa
    Citation: Biological Research 2019 52:21
    Content type: Research Article Published on:

  26. Histone acetylation is an important epigenetic modification that regulates gene activity in response to stress. Histone acetylation levels are reversibly regulated by histone acetyltransferases (HATs) and histone...

    Authors: Fan Wei, Danfeng Tang, Zengqiang Li, Muhammad Haneef Kashif, Aziz Khan, Hai Lu, Ruixing Jia and Peng Chen
    Citation: Biological Research 2019 52:20
    Content type: Research article Published on:

  29. Prunella vulgaris L. has been an important medicinal plant for the treatment of thyroid gland malfunction and mastitis in China for over 2000 years. There is an urgent need to select effective wavelengths for gre...

    Authors: Yuhang Chen, Xuerong Zhang, Qiaosheng Guo, Liping Cao, Qin Qin, Chen Li, Miao Zhao and Wenming Wang
    Citation: Biological Research 2019 52:17
    Content type: Research article Published on:

  30. Sperm production is one of the most complex biological processes in the body. In vitro production of sperm is one of the most important goals of researches in the field of male infertility treatment, which is ...

    Authors: Mahdi Mohaqiq, Mansoureh Movahedin, Zohreh Mazaheri and Naser Amirjannati
    Citation: Biological Research 2019 52:16
    Content type: Research article Published on:

  31. Tumourigenic cells modify metabolic pathways in order to facilitate increased proliferation and cell survival resulting in glucose- and glutamine addiction. Previous research indicated that glutamine deprivati...

    Authors: Mokgadi Violet Gwangwa, Anna Margaretha Joubert and Michelle Helen Visagie
    Citation: Biological Research 2019 52:15
    Content type: Research article Published on:

  32. Drought is a major abiotic stress affecting global wheat (Triticum aestivum L.) production. Exploration of drought-tolerant genes is essential for the genetic improvement of drought tolerance in wheat. Previous s...

    Authors: Xinbo Wang, Yongzhe Ren, Jingjing Li, Zhiqiang Wang, Zeyu Xin and Tongbao Lin
    Citation: Biological Research 2019 52:14
    Content type: Research article Published on:

  33. Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a bet...

    Authors: Tamara Viscarra, Kurt Buchegger, Ignacio Jofre, Ismael Riquelme, Louise Zanella, Michel Abanto, Alyssa C. Parker, Stephen R. Piccolo, Juan Carlos Roa, Carmen Ili and Priscilla Brebi
    Citation: Biological Research 2019 52:13
    Content type: Research article Published on:

  34. Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies. HIF-1α acts as an important transcriptional r...

    Authors: Nishant Kumar Rana, Priya Singh and Biplob Koch
    Citation: Biological Research 2019 52:12
    Content type: Research Article Published on:

  35. The present study aimed to investigate the underlying role of interferon-regulatory factor 2 (IRF2)–inositol polyphosphate-4-phosphatase, type-II (INPP4B) axis in the regulation of autophagy in acute myeloid l...

    Authors: Feng Zhang, Jiajia Li, Junfeng Zhu, Lin Liu, Kai Zhu, Shuang Cheng, RuDi Lv and Pingping Zhang
    Citation: Biological Research 2019 52:11
    Content type: Research Article Published on:

  36. Non-canonical Wnt pathways play important roles in liver fibrosis. Notum is a newly discovered inhibitor to Wnt proteins. This study was to investigate anti-fibrotic effects of Notum.

    Authors: Wenting Li, Xiaolan Yu, Chuanlong Zhu, Zheng Wang, Zonghao Zhao, Yi Li and Yonghong Zhang
    Citation: Biological Research 2019 52:10
    Content type: Research Article Published on:

  37. Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby indu...

    Authors: Guankui Du, Man Xiao, Qiwei Zhu, Chen Zhou, Ao Wang and Wangwei Cai
    Citation: Biological Research 2019 52:9
    Content type: Research article Published on:

  38. Cervical cancer (CC) ranks third in the morbidity and mortality of female cancer around the world. Derlin1 has been found to be overexpressed in several human cancers. However, it is still unclear about its ro...

    Authors: Ling Li, Ming Liu, Zhihu Zhang, Wei Zhang, Naifu Liu, Xiugui Sheng and Ping Wei
    Citation: Biological Research 2019 52:8
    Content type: Letter to the Editor Published on:

  39. Currently, the prognosis of patients with non-small cell lung cancer (NSCLC) remains dismal; hence, it is critical to identify effective anti-NSCLC agents with limited side effects. This study aimed to evaluat...

    Authors: Xiaoli Liu, Qingfeng Jiang, Huaimin Liu and Suxia Luo
    Citation: Biological Research 2019 52:7
    Content type: Research Article Published on:

  40. Pollen development is an energy-consuming process that particularly occurs during meiosis. Low levels of adenosine triphosphate (ATP) may cause cell death, resulting in CMS (cytoplasmic male sterility). DNA se...

    Authors: Xiangjun Kong, Dongmei Liu, Jie Zheng, Aziz Khan, Bin Li, Yong Diao and Ruiyang Zhou
    Citation: Biological Research 2019 52:6
    Content type: Research article Published on:

  41. A moderately thermophilic, slightly halophilic, aerobic, Gram-stain negative, bacterial strain, SLM16, was isolated from a mixed of seawater–sand-sediment sample collected from a coastal fumarole located in Wh...

    Authors: Sebastián L. Márquez and Jenny M. Blamey
    Citation: Biological Research 2019 52:5
    Content type: Research article Published on:

  42. Hematoporphyrin derivative (HPD) has a sensibilization effect in lung adenocarcinoma. This study was conducted to identify the target genes of HPD in lung adenocarcinoma.

    Authors: Hongtao Yin and Yan Yu
    Citation: Biological Research 2019 52:4
    Content type: Research article Published on:

    The Correction to this article has been published in Biological Research 2020 53:16

  44. Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separate...

    Authors: Meysam Moghbeli, Yasha Makhdoumi, Mehrdad Soltani Delgosha, Azadeh Aarabi, Ezzat Dadkhah, Bahram Memar, Abbas Abdollahi and Mohammad Reza Abbaszadegan
    Citation: Biological Research 2019 52:2
    Content type: Research article Published on:

  45. Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer com...

    Authors: Umar Farooq, Sadia Naz, Afshan Shams, Yasir Raza, Ayaz Ahmed, Umer Rashid and Abdul Sadiq
    Citation: Biological Research 2019 52:1
    Content type: Research article Published on:

  46. Studies have demonstrated that transforming growth factor beta-1 (TGF-β1) exhibits oncogenic activity in different types of cancer, including ovarian cancer (OC). However, its regulatory mechanism in OC and wh...

    Authors: Yanqiu Wang, Jun Xiang, Jianjun Wang and Yazhong Ji
    Citation: Biological Research 2018 51:58
    Content type: Research article Published on:

  47. chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it’s impact on heart rate variability and autonomic regulatio...

    Authors: Julio Alcayaga, Rodrigo Del Rio, Esteban A. Moya, Matías Freire and Rodrigo Iturriaga
    Citation: Biological Research 2018 51:57
    Content type: Research article Published on:

  49. The Antarctic continent is a source of extreme microorganisms. Millions of years of isolation have produced unique biodiversity with adaptive responses to its extreme environment. Although the Antarctic climat...

    Authors: Patricio A. M. Flores, Daniela N. Correa-Llantén and Jenny M. Blamey
    Citation: Biological Research 2018 51:55
    Content type: Research article Published on:

  50. Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could regulate cancer cell proliferation important for cancer cell proliferation; however, its role in Hepatocellular carcinoma (HCC) remains largely un...

    Authors: Xuejun Ai, Lei Xiang, Zhi Huang, Shi Zhou, Shuai Zhang, Tao Zhang and Tianpeng Jiang
    Citation: Biological Research 2018 51:52
    Content type: Research article Published on:
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